Our goal is to identify the physical principles governing life and making them available to overcome disease and invent novel smart and robotic materials. Investigating an inherently interdisciplinary challenge spanning biological, statistical physics & mechanics, cell, developmental & synthetic biology as well regenerative medicine we focus on how flow and active, living matter feed back onto each other and thus control the architecture of vascular i.e., flow, networks and their surprisingly complex function. To reach our goal we employ an interplay of experimental observation, quantification of observations and theory and its predictions.